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4SC-202 - HDAC/LSD1 Dual Inhibitor. CAS# 1186222-89-8 size:2 mg solid PubMed Central PMCID: PMC4533741

4SC-202 - HDAC/LSD1 Dual Inhibitor. CAS# 1186222-89-8 size:2 mg solid PubMed Central PMCID: PMC4533741

Name: 4SC-202 - HDAC/LSD1 Dual Inhibitor. CAS# 1186222-89-8 size:2 mg solid PubMed Central PMCID: PMC4533741
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4SC-202 - HDAC/LSD1 Dual Inhibitor. CAS# 1186222-89-8 size:2 mg solid PubMed Central PMCID: PMC45337414SC 202, CAS No. 1186222 89 8, is a potent, selective and orally bioavailable HDAC LSD1 dual Inhibitor. It inhibits class I HDAC with IC50 of 1. 20M, 1. 12 M, and 0. 57M for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). 4SC 202 has very high selectivity over ClassIIa IIb III HDACs. In HeLa cells, it induces hyperacetylation of histone H3 with EC50 of 1. 1 M. It induces a G2 M

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PubMed Central PMCID: PMC4533741

as evidenced by a 23% reduction in epidermal thickness

66(19):9714-21

DASA-58 (ML203)

the combination of Dasatinib and GNF-2 overcame resistance of BCR/ABL-T315I in all models used in a synergistic manner

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