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ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine

ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine

Name: ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotine
Brand: lichtblickpflege-alltagsbegleiter.de
SKU: 87970990701
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SKU: 87970990701

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ONT-093 - CAS# 216227-54-2 0154 Aticaprant (CERC-501) alleviates the nicotineONT 093, CAS No. 216227 54 2, also known as OC 144 093, is an orally bioavailable P glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT 093 could inhibit P gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144 093 is the least non specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60

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Description

Aticaprant (CERC-501) alleviates the nicotine withdrawal syndrome

It inhibits HDAC6 with an enzymatic IC50 ~ 5nM

) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice

PubMed PMID: 23228983

(2011) Cancer Research

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