TM 38837 Catalog No.:M7592-10 GSK429286A slightly inhibits RSK and

GSK429286A slightly inhibits RSK and p70S6K with IC50 of 0

Mcmurtry MS

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

and blocks replicative EBOV growth

5-dihydroxy-6-(hydroxymethyl)-3-{[(2S

TM 38837 Catalog No.:M7592-10 GSK429286A slightly inhibits RSK andHighly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8. 5 nM and 605 nM for inhibition of [3H] CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71 fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1 overexpressing cell membranes in vitro (EC50 = 18. 5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice. Product