LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 MERcK-5 reduces IFN-γ and IL-13

MERcK-5 reduces IFN-γ and IL-13

PubMed Central PMCID: PMC3754927

It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference

it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status

515(7527):443-7

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 MERcK-5 reduces IFN-γ and IL-13LY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is