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IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 1186/scrt163

IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 1186/scrt163

Name: IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 1186/scrt163
Brand: lichtblickpflege-alltagsbegleiter.de
SKU: 65671410353
Price: 129.00 USD
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SKU: 65671410353

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IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 1186/scrt163IRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to

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Description

1186/scrt163

with an IC50 of 14 nM

InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

In soft agar

and p62 degradation

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