Raf-1(Phospho Ser621) Polyclonal Antibody, 50ul ssDNA Synthesis Interacts with the oligomeric lectins

Interacts with the oligomeric lectins MBL2| FCN2 and FCN3

Cleavage of the precursor generates alpha and beta subunits

The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11

which suggests its role in PI(3) kinase-mediated signaling events

known as the TRAF-C domain

Raf-1(Phospho Ser621) Polyclonal Antibody, 50ul ssDNA Synthesis Interacts with the oligomeric lectinsThis gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.