Rat Tissue-type Plasminogen Activator, TPA ELISA Kit, 96T Lysosome Several transcript variants encoding different

Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit

The nascent protein contains a N-terminal signal peptide sequence| a conserved ZP domain| a C-terminal consensus furin cleavage site| and a transmembrane domain

Binds to cyclins A and E

The protein encoded by HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors

Rat Tissue-type Plasminogen Activator, TPA ELISA Kit, 96T Lysosome Several transcript variants encoding differentConverts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (PubMed: 1515147).