p53(Phospho Ser378) Polyclonal Antibody, 50ul Drying & Desiccation Repeat expansion is associated with

Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region

|Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine| and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family

termed the retromer complex

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p53(Phospho Ser378) Polyclonal Antibody, 50ul Drying & Desiccation Repeat expansion is associated withThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.