PPM1E Polyclonal Antibody, 50ul Plates & Dishes May be required for pre-mRNA

May be required for pre-mRNA splicing

suggesting that it is required for kinetochore formation

and the regulation of cell growth

A mutation in this gene was associated with Birk-Barel mental retardation dysmorphism syndrome

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum

PPM1E Polyclonal Antibody, 50ul Plates & Dishes May be required for pre-mRNAThis gene encodes a member of the PPM family of serine threonine protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine threonine protein kinase PAK 1, 5' AMP activated protein kinase (AMPK) and the multifunctional calcium calmodulin dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.