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Spastic paraplegias are a diverse group of disorders in which the autosomal dominant forms are characterized by progressive| lower extremity spasticity caused by axonal degeneration in the terminal portions of the longest descending and ascending corticospinal tracts

The protein encoded by this gene belongs to the TYR family of protein kinases

A mutation in this gene results in somatostatin analog resistance

This protein is assembled into a nucleoprotein complex that is involved in the repair of DNA lesions

EWS Polyclonal Antibody, 100ul Cryogenic Vials Conquer any lab challenge withEWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N terminal transcriptional activation domain and a C terminal RNA binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These