Dysferlin Polyclonal Antibody, 50ul ADME and the COOH-terminal part translocates

and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release

This gene belongs to the VCX/Y gene family| which has multiple members on both X and Y chromosomes| and all are expressed exclusively in male germ cells

Upregulated expression of this gene in astroglial cells upon exposure to lipopolysaccharides suggests a function for the encoded protein in the brain

The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations

Low expression in heart

Dysferlin Polyclonal Antibody, 50ul ADME and the COOH-terminal part translocatesThe protein encoded by DYSF (dysferlin) belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by DYSF binds caveolin 3, a skeletal muscle membrane protein which is important in the